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Genetic Research Stanford-led Team Finds Non-African Human Populations Harbor Higher Mutational Loads

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Dec 29 2015

"Out-of-Africa human populations are more likely to harbor higher mutational loads, a Stanford University School of Medicine-led team has found.

Stanford's Carlos Bustamante and his colleagues analyzed the genomes and exomes of seven geographically divergent human populations — from Namibia, Congo, Algeria, Pakistan, Cambodia, Siberia, and Mexico — and found that while the number of deleterious alleles in each individual varies only a little, classes of deleterious alleles show different patterns across those populations. These patterns seem to stem from the interaction of genetic drift and purifying selection, as the researchers reported in the Proceedings of the National Academy of Sciences this week."